Regular physical activity not only changes your body, it change

Late-life physical activity relates to brain tissue synaptic integrity markers in older adults

Kaitlin Casaletto 1, Alfredo Ramos-Miguel 2, Anna VandeBunte 1, Molly Memel 3, Aron Buchman 4, David Bennett 4, William Honer 5 6

Affiliations expand

• PMID: 34994517
•  
• PMCID: PMC9259753 (available on 2023-07-07)
•  
• DOI: 10.1002/alz.12530

Abstract

Introduction: Physical activity (PA) is widely recommended for age-related brain health, yet its neurobiology is not well understood. Animal models indicate PA is synaptogenic. We examined the relationship between PA and synaptic integrity markers in older adults.

Methods: Four hundred four decedents from the Rush Memory and Aging Project completed annual actigraphy monitoring (Mean visits = 3.5±2.4) and post mortem evaluation. Brain tissue was analyzed for presynaptic proteins (synaptophysin, synaptotagmin-1, vesicle-associated membrane proteins, syntaxin, complexin-I, and complexin-II), and neuropathology. Models examined relationships between late-life PA (averaged across visits), and timing-specific PA (time to autopsy) with synaptic proteins.

Results: Greater late-life PA associated with higher presynaptic protein levels (0.14 < β < 0.20), except complexin-II (β = 0.08). Relationships were independent of pathology but timing specific; participants who completed actigraphy within 2 years of brain tissue measurements showed largest PA-to-synaptic protein associations (0.32 < β < 0.38). Relationships between PA and presynaptic proteins were comparable across brain regions sampled.

Discussion: PA associates with synaptic integrity in a regionally global, but time-linked nature in older adults.

Keywords: actigraphy; cognitive resilience; exercise; presynaptic protein.

© 2021 the Alzheimer's Association.

Conflict of interest statement

Conflicts of interest: The authors have no relevant conflicts of interest to disclose.

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